Combination therapy prevents extravascular leukemic burden. (A) Combination treatment was separated by 24 hours and administered for 1 week (n = 2-4). On day 20, ovaries were photographed for macroscopic size comparison. (B) Combination treatment was separated by 24 hours and repeated for 3 weeks (n = 5). On day 20, total liver weights are compared. (C) Representative ovary, liver, and kidney histology with H&E staining on day 20. Scale bars as noted in the figures (250 μm for ovary; 100 μm for periadnexal soft tissue, liver [high power], and renal hilar adipose tissue; 1 mm for liver [low power] and kidney). H&E, hematoxylin and eosin.