Figure 4.
LMP1-related mimotopes that activate 58-11A5. (A) Results of an NCBI protein BLAST search (https://blast.ncbi.nlm.nih.gov, accessed in October 2023) of the human proteome (taxid:9606) using “WQLLAFFLA” as input sequence. Sequences to be tested for 58-11A5 activation (highlighted in yellow) were selected by investigators’ choice considering numbers and positions as well as size, charge, and hydrophobicity of exchanged amino acids. Amino acids that differ from the LMP1 target peptide are colored in red. (B) Mimotopes that activated 58-11A5. The LMP1 epitope WQLLAFFLA was included as positive control, GFPT1-derived LQLLAFHLA was shown as negative control and representative example for peptides that did not activate 58-11A5. Amino acids that differ from WQLLAFFLA are colored in red. The plot shows frequencies of GFP+ as percentage of 58α−β− cells. Data indicate median ± standard deviation of n = 3 replicates.

LMP1-related mimotopes that activate 58-11A5. (A) Results of an NCBI protein BLAST search (https://blast.ncbi.nlm.nih.gov, accessed in October 2023) of the human proteome (taxid:9606) using “WQLLAFFLA” as input sequence. Sequences to be tested for 58-11A5 activation (highlighted in yellow) were selected by investigators’ choice considering numbers and positions as well as size, charge, and hydrophobicity of exchanged amino acids. Amino acids that differ from the LMP1 target peptide are colored in red. (B) Mimotopes that activated 58-11A5. The LMP1 epitope WQLLAFFLA was included as positive control, GFPT1-derived LQLLAFHLA was shown as negative control and representative example for peptides that did not activate 58-11A5. Amino acids that differ from WQLLAFFLA are colored in red. The plot shows frequencies of GFP+ as percentage of 58α−β− cells. Data indicate median ± standard deviation of n = 3 replicates.

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