Desmopressin responses in low VWF compared with WiN type 1 VWD subgroups. Plasma VWF:Ag were determined prior to desmopressin administration (T0), and at 1 (T + 1), 4 (T + 4), and 24 (T + 24) hours after desmopressin administration. The mean and standard deviations are depicted; n = 226 before desmopressin administration; n = 217 at 1 hour; n = 146 at 4 hours; and n = 126 at 24 hours. Significantly reduced VWF responses were observed at all postdesmopressin time points in the WiN persistent <30 IU/dL subgroup. Plasma VWF:Ag levels at 1, 4, and 24 hours after desmopressin were significantly higher in WiN-normalized than in LoVIC patients. ns, not significant.