Figure 6.
The globular domain of FGL1 mediates hepcidin suppression. (A) AlphaFold structure prediction of mouse FGL1. (B) Schematic representation of the recombinant mouse FGL1 protein constructs. HAMP (C) and ID1 (D) expression in Hep3B cells and mouse primary hepatocytes treated for 6 hours with BMP6 and either Fc, FL, or the N-terminal (Nter) or globular (glob) domains of FGL1. Data shown are mean ± SEM of 3 independent experiments (C-D) and were compared with Fc-treated cells using 1-way ANOVA and corrected for multiple comparisons using the Holm-Šidák method. ∗∗∗∗P < .0001; ∗∗∗P < .001; ∗∗P < .01; ∗P < .05.

The globular domain of FGL1 mediates hepcidin suppression. (A) AlphaFold structure prediction of mouse FGL1. (B) Schematic representation of the recombinant mouse FGL1 protein constructs. HAMP (C) and ID1 (D) expression in Hep3B cells and mouse primary hepatocytes treated for 6 hours with BMP6 and either Fc, FL, or the N-terminal (Nter) or globular (glob) domains of FGL1. Data shown are mean ± SEM of 3 independent experiments (C-D) and were compared with Fc-treated cells using 1-way ANOVA and corrected for multiple comparisons using the Holm-Šidák method. ∗∗∗∗P < .0001; ∗∗∗P < .001; ∗∗P < .01; ∗P < .05.

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