Expansion and persistence of CD5.CAR T cells after infusion. (A) Levels of the CD5.CAR transgene per mL of blood. The area under the curve (AUC) for each dose level over the first 3 weeks is plotted on a bar graph. (B,C) Levels of the CD5.CAR transgene in patients no. 5 (B) and no. 31 (C), who received a second dose of CD5.CAR T cells. (D) CD5.CAR transgene levels and 3-week AUC in responders (Rs) and nonresponders (NRs). Statistical significance was evaluated using the unpaired Student t test.