Location of DC-SIGN⁺ cells in the FL TME. Cell DIVE-IBEX images depicting location of cell types expressing DC-SIGN in non-FL and FL LNs and IRF4⁺BCL2⁺ tumor B cells in close proximity to DC-SIGN⁺ macrophages outside of the follicles. Scale bar, 50 μm (large images) and 25 μm (insets). Arrows show contact between DC-SIGN⁺ macrophages and IRF4⁺ cells. FDCs and DC-SIGN⁺ macrophages (MΦ). DC-SIGN⁺ macrophages defined by morphology and location in the LN.