Stromal remodeling and ECM deposition in FL TME. Cell DIVE-IBEX images of tissue sections from excisional LN biopsies. Non-FL LN, scale bar, 150 μm. FL overview, scale bar, 2 mm. (Insets 1-2) Images depict heterogeneity in the amount of ECM (lumican); scale bars, 150 μm. (Insets 3) Stromal diversity using indicated markers; scale bar, 50 μm. α-SMA, α-smooth muscle actin; IBEX, iterative bleaching extends multiplexity; SPARC, secreted protein acidic and rich in cysteine.