DLBCL LME categories. Gene expression classification of “immune rich” and “immune deserted” DLBCL TMEs into: (clockwise) GC-LME, MS-LME, DP-LME, and IN-LME. The proportion of GCB-like and ABC-like DLBCLs per LME category is indicated. GC- and MS-LMEs carry comparatively better prognosis than IN- and DP-LMEs. DLBCL genetic classes associated with LMEs are indicated: MCD with IN- and DP-LMEs and BN2, ST2, and EZB with “immune deserted” LME categories. Representative TME cell subtypes and functions as well as pathways activated in lymphoma cells are shown for each LME category. CAF, cancer-associated fibroblasts; FTH, follicular T helper cell; ECM, extracellular matrix; FDC, follicular dendritic cells; FRC, fibroblastic reticular cells; TAN, tumor-associated neutrophils; TAM, tumor-associated macrophages; Treg, regulatory T cell; VEC, vascular endothelial cells; VLC, vascular lymphatic cells; MDSC, myeloid-derived suppressor cells.