The potential influence of mandatory oligomannoses inserted into the BCR during the development of FL. The first event in the bone marrow is t(14;18) translocation, which upregulates BCL2. These B cells then, apparently, undergo somatic hypermutation (SHM) and antigen selection. There is a likely bifurcation of cells that are able to bind antigen and those that have acquired oligomannoses in the BCR, which cannot undergo antigen selection. These “rejects” may be lost or could be rescued by DC-SIGN on FDCs and/or macrophages, forming a population awaiting mutations in chromatin-modifying genes (CMGs) to drive lymphomagenesis.