Figure 5.
Hemin-induced suppression of BM erythropoiesis was attenuated in IFN-1 receptor knockout mice. (A) Fold change of BFU-E colony numbers, CFU-E colony numbers, and erythroblast numbers in the BM of PBS- or hemin-injected WT B6 or Ifnar1−/− mice (N = 6). (B-C) Representative western blot and quantitative analyses of Stat2 levels in enriched BM erythroid cells of PBS-, hemin- or IFNα-injected WT B6 or Ifnar1−/− mice (N = 3). ∗P < .05; ∗∗∗P < .001.

Hemin-induced suppression of BM erythropoiesis was attenuated in IFN-1 receptor knockout mice. (A) Fold change of BFU-E colony numbers, CFU-E colony numbers, and erythroblast numbers in the BM of PBS- or hemin-injected WT B6 or Ifnar1−/− mice (N = 6). (B-C) Representative western blot and quantitative analyses of Stat2 levels in enriched BM erythroid cells of PBS-, hemin- or IFNα-injected WT B6 or Ifnar1−/− mice (N = 3). ∗P < .05; ∗∗∗P < .001.

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