Inflammatory signaling considering effects by soluble complement and CRs of the integrin family, in addition to sensing pathogen-associated molecular patterns (PAMPs) via pattern recognition receptors. ANA, complement anaphylatoxins C3a and C5a; C3 act. cycle, C3 activation cycle; C3 reg. cycle, C3 regulation cycle; MAC, complement membrane attack complex. Professional illustration by Somersault18:24.