Correlated expression and putative functions of oncogenic circFKBP5, circKLHL2, circNR3C1, and circPAN3 ectopically expressed in KMT2A::AFF1 ALL. CircFKBP5, circKLHL2, circNR3C1, and circPAN3 (A) pairwise expression correlation in a cohort of 17 pediatric patients with KMT2A::AFF1 ALL; (B) miRNA-binding sites predicted by CRAFT; (C) venn diagram of the overlap of validated target genes (TGs) of miRNAs potentially bound by circFKBP5, circKLHL2, circNR3C1 and circPAN3; overrepresentation of (D) biological processes; and (E) diseases among genes commonly linked, through miRNAs, to at least 3 of the 4 oncogenic circRNAs identified and with positive LFC comparisons of KMT2A::AFF1 ALL samples with CD34⁺ cells from HDs.