Distinct transcriptional profiles in BCMA iPSC-HPCs that commit to antigen-specific CD8⁺ T cells or other cell lineages (expanded analysis of >10 000 genes). (A) Venn diagrams illustrating “uniquely” or “commonly” expressed genes, either upregulated (left) or downregulated (right) in the iPSC-HPCs that differentiate into CD8⁺ T cells as compared with other lineages: iPSC-HPC (CD3⁻ lymphocytes), iPSC-HPC (nonlymphocytes), or primary HPC from the blood (log2 fold change >2 : P_adj < .05). (B, left) GO annotation analysis (−log 10 [P value]) identified “commonly” upregulated genes (57 genes) in iPSC-HPC (CD8⁺ T cells). (B, right) GO enrichment of specific categories related to immune response or inflammatory response in iPSC-HPCs that differentiate into CD8⁺ T cells.