Changes in circulating FVIII activity. (A-B) Individual plots showing FVIII activity for individual participants in all cohorts over time based on the chromogenic (A) and 1-stage (B) assays. (C-D) Box and whisker plots showing the group mean (diamond) and median (horizontal line) with quartiles (blue boxes) and minimum to maximum (whiskers) of FVIII activity in cohort 4 at each assessment using the chromogenic (C) and 1-stage (D) assays. (A-D) For results reported as below the limit of quantitation, a value of 0.009 IU/mL (0.9%) was used for analysis and plotting.