Anti-erythrocyte antibodies, for AMIS and potentially in the context of immunotherapies or acquired blood phenotypes, bind their corresponding RBC antigens and either induce trogocytosis-mediated antigen loss or lead to phagocytic clearance of IgG-sensitized RBCs by macrophages. This balance may be controlled by several factors including antigen density and structure at the membrane, antibody concentration and biological properties, and the interaction of the antigen with membrane proteins. The figure was adapted from the visual abstract in the article by Cruz-Leal et al that begins on page 807.