Figure 3.
MIR155HGΔexon3 T cells persist with lower Th1 cell population in circulation. Flow cytometry was performed on peripheral blood cells obtained from facial bleeds of xeno-GVHD mice that received 10 × 106 MIR155HGΔexon3 or NT human T cells. Each point represents an independent mouse receiving either MIR155HGΔexon3 or NT control human T cells. (A) Percentage of CD3+ T cells over time from a single representative donor is shown, n = 5 per cohort. (B-G) Mice were bled through cardiac puncture on day 35 after transplantation, data combined from 2 to 3 independent donors, n = 8 to 12 per cohort. (B) Percentage CD3+ T cells. (C) Percentage CD4+ and CD8+ T cells subsets. (D) CCR4 and CCR10 expressing CD3+ T cells. (E) Proportion of Th1, Th17, and Treg CD4+ T-cell subtypes. LAG3, Tim3, and PD1 expression on (F) CD4+ T cells and (G) CD8+ T cells (∗P < .05, ∗∗P < .01, ∗∗∗P < .001).

MIR155HGΔexon3 T cells persist with lower Th1 cell population in circulation. Flow cytometry was performed on peripheral blood cells obtained from facial bleeds of xeno-GVHD mice that received 10 × 106 MIR155HGΔexon3 or NT human T cells. Each point represents an independent mouse receiving either MIR155HGΔexon3 or NT control human T cells. (A) Percentage of CD3+ T cells over time from a single representative donor is shown, n = 5 per cohort. (B-G) Mice were bled through cardiac puncture on day 35 after transplantation, data combined from 2 to 3 independent donors, n = 8 to 12 per cohort. (B) Percentage CD3+ T cells. (C) Percentage CD4+ and CD8+ T cells subsets. (D) CCR4 and CCR10 expressing CD3+ T cells. (E) Proportion of Th1, Th17, and Treg CD4+ T-cell subtypes. LAG3, Tim3, and PD1 expression on (F) CD4+ T cells and (G) CD8+ T cells (∗P < .05, ∗∗P < .01, ∗∗∗P < .001).

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