TG and TD parameters in patients with APS (n = 48) and control participants (n = 64) in the neural network developmental cohort. (A-C) TG parameters lag time (A), peak height (B), and time-to-peak (C) did not differ significantly between patients with APS and controls on VKA treatment. (D-E) The ETP (D) was significantly lower in patients with APS than controls; whereas the velocity index (E) was significantly higher. (F) The inhibitory effect of TM on the peak height was significantly less in patients with APS compared with controls. (G-K) TD parameters PC_tot (G), thrombin-AT (T-AT) complex formation (J), T-α2M formation (K) were comparable between anticoagulated patients with APS and controls; (H, I) PC_max was significantly increased in patients with APS (H), and the PC_max was less sensitive to the inhibitory actions of TM (I). (L) The thrombin decay capacity was significantly higher in patients with APS than controls. Differences between group means were analyzed using the Mann-Whitney test. ∗P < .05; ∗∗∗P < .001; ∗∗∗∗P < .0001. Data are shown as median and interquartile ranges.