Relationship between nonsynonymous mutation enrichment and risk of hematologic malignancy. Gene-specific HRs for hematologic neoplasm (as calculated in Figure 2) are plotted as a function of context-corrected nonsynonymous mutation enrichment (dNdScv). High-risk CH genotypes identified in Figure 2 are labeled in red, whereas other selected genotypes are labeled in blue. Kendall τ statistic was used to quantify the relationship (centered, top). A linear trend line is displayed for visual reference.