Spatial heterogeneity of CD20 loss. (A) Schematic illustration showing the spatial response heterogeneity in patient 3 to CD20-targeted bispec therapy. (B) UMAP representation of single-cell transcriptomes (25 824 cells) from samples 3.2 and 3.3 colored by sample. Dashed outlines delineate cell type clusters. The schematic was partially created using BioRender.com.