cBAF inhibition impairs leukemic growth in a cell-autonomous manner. (A) Fourteen-day competitive coculture assay of Jurkat cells transduced with gRNAs targeting the indicated genes. Data are shown as mean ± SD (n = 3). (B-C) Drug sensitivity assay of BRM014 and AU-15330 in the indicated T-ALL cell lines (B) and T-ALL PDX cells (C). Data are shown as mean (n = 3). (D-E) Percentage of annexin V–positive in the indicated knockout Jurkat cells (D) and human T-ALL cell lines treated with BRM014 or AU-15330 (E). Data are shown as mean ± SD (n = 3). Two-tailed Student t test was used to assess statistical significance in panels D and E (∗∗∗P < .001; ∗∗P < .01; ∗P < .05). gRNA, guide RNA; SD, standard deviation.