The cBAF complex is required for migration and survival of T-ALL. In a genome-wide CRISPR screen aimed at identifying regulators of migration of T-ALL cells toward CXCL12, Aoki et al discovered that the ATP-dependent chromatin remodeling cBAF complex is required for CXCR4 expression, CXCL12 migration, and T-ALL survival. cBAF regulates chromatin in T-ALL cells in a manner that allows for the transcription factor RUNX1 to access promoter and drive expression of CXCR4 and CDK6. As such, small molecule inhibitors and degraders of cBAF result in death of T-ALL cells.