Hematological toxicities after CD28-costimulated CART19 infusion according to LD regimen administered. (A) Hematological toxicities within 30 days after axi-cel infusion. Dot plots show differences between the 2 LD regimens for lowest neutrophil count, platelet count, and hemoglobin levels within 30 days after axi-cel infusion. Shadows of purple background highlight the range of specific abnormal levels. (B) Incidence of severe neutropenia (G3: light purple; G4: purple) events according to LD within 30 days after axi-cel infusion; (C) incidence of severe thrombocytopenia (G3: light purple; G4: purple) events according to LD within 30 days after axi-cel infusion; (D) blood counts over time according to LD regimen. Red lines represent patients treated with Flu/Cy, whereas blue lines represent patients treated with Benda. (E) Long-term hematological toxicities at 6 months after axi-cel infusion in patients with ongoing remission. Dot plots show differences between the 2 LD regimens for lymphocyte count, neutrophil count, platelet count, and hemoglobin levels. Each dot represents a single patient. Shadows of purple background highlight the range of specific abnormal levels. ∗P < .050; ∗∗P < .005; and ∗∗P < .001; ns, not statistically significant.