Perioperative apixaban management in patients with advanced chronic kidney disease. Apixaban interruption and resumption intervals in hours, stratified according to procedural bleed risk. Intervals represent the time between last dose of apixaban before the procedure and the procedure itself, approximated to the nearest 12 hours. Apixaban was not resumed after the procedure for 1 patient undergoing a low-bleed-risk procedure and 4 patients undergoing high-bleed-risk procedures. The median interruption and resumption intervals for patients undergoing low/moderate-bleed-risk procedures was 84 hours (IQR 60-84) and 24 hours (IQR 24-48), respectively. The median interruption and resumption intervals for high-bleed-risk procedures was 84 hours (IQR 60-84) and 48 hours (IQR 24-72), respectively. Interruption intervals were not significantly different according to procedural bleed risk (P= 0.38), but patients who had undergone a high-bleed-risk procedure had significantly longer resumption intervals (P= 0.0037).