CMRO₂ changes before and after transplant and compared with healthy controls. (A) CMRO₂ changes in adults with SCD before and after HSCT (haplo-BMT). Individual participant changes are shown overlayed on the symbol and line graph, whereas group data are shown in violin plots with the bolded dashed line showing the median and smaller dashed lines showing the upper and lower quartiles for subjects before (blue plot) and after transplant (green plot). (B) Box-and-whisker plots of CMRO₂ shown in healthy adults (left; red dots) and in adults with SCD before transplant (middle; blue dots) and 1 year after transplant (right; green dots). CMRO₂ does not show significant differences between controls and patients with SCD either before transplant (P = .18) or after transplant (P = .99).