CBF changes before and after transplant and in relation to those in controls. (A) CBF changes in adults with SCD before and after HSCT. CBF significantly decreases after HSCT (P = .003). Individual participant changes are shown overlayed on the symbol and line graph, whereas group data are shown in violin plots, with the bolded dashed line showing the median and smaller dashed lines showing the upper and lower quartiles for participants before (blue plot) and after transplant (green plot). (B) Box-and-whisker plots of CBF shown in healthy adults (left; red dots) and in adults with SCD before transplant (middle; blue dots) and 1 year after transplant (right; green dots). CBF is significantly elevated in patients with SCD before transplant (P = .004) and reduces to levels similar to healthy adults after transplant (P = .777).