Mouse pharmacokinetic study of PA4. (A) PA4 concentration in serum and tumor tissues after the 14 day PA4 treatment in NSG mice shown in Figure 5. Data are shown as mean with SD. (B) Mean plasma concentration-time profiles of BBM (top) and PA4 (bottom) in Institute of Cancer Research mice after IV and oral administrations (n = 3). (C) PA4 concentration in serum from mice that received oral gavage with PA4 for 2 weeks, 4 weeks, or 2 weeks plus 2 weeks without treatment.