PA4 inhibits tumor growth in vivo. (A) Scheme of H9-induced lymphoma in NSG mouse model, and pharmacological inhibition by PA4. Representative images of tumors (B) and tumor growth curve (C) of NSG mice treated with either PBS, BBM, or PA4. (D) Tumor size at end point of the 30th day. ∗∗P < .01 vs PBS group; ^##P < .01 vs PA4 5-mg/kg group. (E) Body weight of mice in indicated groups. No statistical significance (ns) vs PBS group. (F) Representative western blot analysis of CAMKIIγ and c-Myc protein in tumor tissues from PA4 and PBS groups. GAPDH is used as loading control. (G) Representative images of hematoxylin and eosin (H&E) and immunohistochemical staining of c-Myc with sections of tumors from PA4 and PBS groups.