Figure 3.
Presence of stem-like TIL markers on CD19 CAR T cells. (A) Percentage of stem-like CD39−CD69− population in CD3+CD34+ cells transduced either after IL-7 culture or CD3 activation. The graph depicts each data point from 5 donors with lines connecting data points from an individual donor. Statistics were calculated by 2-tailed Wilcoxon rank sum test. ∗∗P = .0079. (B) Flow cytometry analysis depicting TN/TSCM (CD62L+CD45RA+), TCM (CD62L+CD45RA−), TEM (CD62L−CD45RA−), and TEFF (CD62L−CD45RA−) populations in CD3+CD34+CD39−CD69− and CD3+CD34+CD39+CD69+ cells transduced either after IL-7 culture or CD3 activation. Graphs are representative of 5 experiments using cells from 5 different donors.

Presence of stem-like TIL markers on CD19 CAR T cells. (A) Percentage of stem-like CD39CD69 population in CD3+CD34+ cells transduced either after IL-7 culture or CD3 activation. The graph depicts each data point from 5 donors with lines connecting data points from an individual donor. Statistics were calculated by 2-tailed Wilcoxon rank sum test. ∗∗P = .0079. (B) Flow cytometry analysis depicting TN/TSCM (CD62L+CD45RA+), TCM (CD62L+CD45RA), TEM (CD62LCD45RA), and TEFF (CD62LCD45RA) populations in CD3+CD34+CD39CD69 and CD3+CD34+CD39+CD69+ cells transduced either after IL-7 culture or CD3 activation. Graphs are representative of 5 experiments using cells from 5 different donors.

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