Correlates of treatment response and resistance. (A) Serial bone marrow aspirate samples analyzed using multiparameter flow cytometry visualized using t-distributed Stochastic Neighbor Embedding (t-SNE) plots generated by Cytobank. (B) Correlating 2-HG data from serial plasma samples. (C) Serial bone marrow aspirate samples taken at baseline, CR and relapse were analyzed using the ArcherDX’s FusionPlex Myeloid and VariantPlex Myeloid panels.