CAR T-cell kinetics in patients treated with JCAR014 with and without durvalumab. (A) CAR T-cell counts in the blood by qPCR in groups 1 and 2 (NCT02706405) and JCAR014 alone (NCT01865617) cohorts. Each thin line represents a single patient; bold lines represent the averaged data using local polynomial regression (LOESS) curve fitting approximation with the standard error in gray. (B) Time to CAR T-cell peak counts in the blood by qPCR in groups 1 and 2 (NCT02706405) and the JCAR014 alone (NCT01865617) cohorts. Mann-Whitney tests were used to compare differences between the groups.