PFS by relapse subgroup (<24 and ≥24 months) in CASTOR. Kaplan-Meier plot of PFS in patients with 1 prior line of therapy who progressed or relapsed early or late after initiation of first line of therapy. The early-relapse subgroup included ITT patients with 1 prior line of therapy who progressed or relapsed <24 months after initiating their first line of therapy; the late-relapse subgroup included ITT patients with 1 prior line of therapy who progressed or relapsed ≥24 months after initiating their first line of therapy.