scDNA-seq characterization of distinct clonal evolution patterns in Dx_Rel T-ALL pairs from diagnosis to relapse. (A-D) Fish plots showing dynamic clonal prevalence over time of the 4 patients, T723 (A), T956 (B), T593 (C), and T856 (D), each with a distinct pattern of clonal progression from diagnosis to relapse, with annotations for the genomic alterations in each clone. The left-most clonal composition in each plot represents a snapshot of founder clonal architecture at diagnosis, rather than the parental clones from which all leukemic cells were derived.