Figure 5.
Genetic and pharmacological inhibition of PRL2 decreases leukemia burden and extends the survival of mice transplanted with human leukemia cell lines. (C) Kaplan-Meier survival curve of sublethally irradiated NSG mice transplanted with 3 × 106 MV-4-11 cells expressing shCtrl or shPRL2 (n = 7 mice per group). (J) Kaplan-Meier survival curve of NSG mice treated with DMSO or PRLi (n = 7 mice per group). DMSO, dimethyl sulfoxide; PRLi, PRL inhibitor; shCtrl, control shRNA.

Genetic and pharmacological inhibition of PRL2 decreases leukemia burden and extends the survival of mice transplanted with human leukemia cell lines. (C) Kaplan-Meier survival curve of sublethally irradiated NSG mice transplanted with 3 × 106 MV-4-11 cells expressing shCtrl or shPRL2 (n = 7 mice per group). (J) Kaplan-Meier survival curve of NSG mice treated with DMSO or PRLi (n = 7 mice per group). DMSO, dimethyl sulfoxide; PRLi, PRL inhibitor; shCtrl, control shRNA.

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