Potential translational role of single-cell genomics in hemato-oncology diagnostics. Complementing the current repertoire of tests applied at diagnosis, remission, and relapse, we anticipate that the addition of single-cell genomics techniques has the potential to delineate clonal composition, track rare populations through remission and relapse, and identify transcriptional signatures that predict treatment response or resistance. NGS, next-generation sequencing; PCR, polymerase chain reaction. Figure created with BioRender.com.