Effects of IQ on platelet aggregation. Mean agonist-induced platelet aggregation shown as change from the baseline in impedance whole-blood aggregometry from patients from the IQ group (n = 22) and the placebo group (n = 22). IQ treatment only shows a significant effect on platelet aggregation after exposure to (A) low doses of collagen (ANCOVA, ∗P = .02; IQ, n = 21; placebo, n = 21); however, after standard platelet aggregation, agonists such as (B) thrombin, (C) adenosine 5′-diphosphate (ADP), (D) arachidonic acid, and (E) high dose of collagen (ANCOVA, P = .93, P = .72, P = .63, and P = .66; respectively) did not show any effect.