Figure 2.
IPSS-M prognostic risk schema. The main effect genes are shown on the left in a statistically weighted order (top having the most adverse risk). Residual genes are included as additives (maximum of 2 genes). These mutations are incorporated into the algorithm, which also includes cytopenias, marrow blasts, and cytogenetic abnormalities, to calculate the IPSS-M score and risk category. SF3B15q = SF3B1 mutation with isolated del(5q) or with 1 additional aberration excluding –7/del(7q). SF3B1α = SF3B1 mutation without comutations in BCOR, BCORL1, RUNX1, NRAS, STAG2, SRSF2, or del(5q). H, high; L, low; MH, moderate high; ML, moderate low; VH, very high; VL, very low risk. Adapted with permission from Bernard et al.68 These results may be accessed via a web-based URL: https://mds-risk-model.com.