Model of FL pathogenesis with integration of genetic and immunologic drivers. The findings of Haebe et al are highlighted by the peach-colored field. Occurrence of lymphomagenic driver events is highlighted in red. AID, activation-induced deaminase; BCL2, B-cell lymphoma 2 gene; BCR, B-cell receptor; CSR, class switch recombination; DZ, dark zone; FLLC, FL-like cell; GC, germinal center; GEP, gene expression profile; IgH, immunoglobulin heavy chain; SHM, somatic hypermutation. Professional illustration by Patrick Lane, ScEYEnce Studios.

Model of FL pathogenesis with integration of genetic and immunologic drivers. The findings of Haebe et al are highlighted by the peach-colored field. Occurrence of lymphomagenic driver events is highlighted in red. AID, activation-induced deaminase; BCL2, B-cell lymphoma 2 gene; BCR, B-cell receptor; CSR, class switch recombination; DZ, dark zone; FLLC, FL-like cell; GC, germinal center; GEP, gene expression profile; IgH, immunoglobulin heavy chain; SHM, somatic hypermutation. Professional illustration by Patrick Lane, ScEYEnce Studios.

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