American Society of Hematology

Figure 6.

$Staining patterns and expression levels of 5 selected apoptotic markers. (A) Representative images of immunohistochemical staining patterns of CASP3 expression (left, original magnification ×5; right, original magnification ×20). (B) CASP3 expression levels identified by MS-based proteomics. (C) CASP3 expression levels identified by immunohistochemical staining in whole biopsy and intrafollicular areas. (D) Representative images of immunohistochemical staining patterns of MCL1 expression (left, original magnification ×5; right, original magnification ×20). (E) MCL1 expression levels identified by MS-based proteomics. (F) MCL1 expression levels identified by immunohistochemical staining in whole biopsy and intrafollicular areas. (G) Representative images of immunohistochemical staining patterns of BAX expression (left, original magnification ×5; right, original magnification ×20). (H) BAX expression levels identified by MS-based proteomics. (I) BAX expression levels identified by immunohistochemical staining in whole biopsy and intrafollicular areas. (J) Representative images of immunohistochemical staining patterns of BCL-xL expression (left, original magnification ×5; right, original magnification ×20). (K) BCL-xL expression levels identified by MS-based proteomics. (L) BCL-xL expression levels identified by immunohistochemical staining in whole biopsy and intrafollicular areas. (M) Representative images of immunohistochemical staining patterns of BCL-rambo expression (left, original magnification ×5; right, original magnification ×20). (N) BCL-rambo expression levels identified by MS-based proteomics. (O) BCL-rambo expression levels identified by immunohistochemical staining in whole biopsy and intrafollicular areas. ▪P < .1; ∗P < .05; ∗∗P < .01; ∗∗∗P < .001. AF, area fraction.$

Staining patterns and expression levels of 5 selected apoptotic markers. (A) Representative images of immunohistochemical staining patterns of CASP3 expression (left, original magnification ×5; right, original magnification ×20). (B) CASP3 expression levels identified by MS-based proteomics. (C) CASP3 expression levels identified by immunohistochemical staining in whole biopsy and intrafollicular areas. (D) Representative images of immunohistochemical staining patterns of MCL1 expression (left, original magnification ×5; right, original magnification ×20). (E) MCL1 expression levels identified by MS-based proteomics. (F) MCL1 expression levels identified by immunohistochemical staining in whole biopsy and intrafollicular areas. (G) Representative images of immunohistochemical staining patterns of BAX expression (left, original magnification ×5; right, original magnification ×20). (H) BAX expression levels identified by MS-based proteomics. (I) BAX expression levels identified by immunohistochemical staining in whole biopsy and intrafollicular areas. (J) Representative images of immunohistochemical staining patterns of BCL-xL expression (left, original magnification ×5; right, original magnification ×20). (K) BCL-xL expression levels identified by MS-based proteomics. (L) BCL-xL expression levels identified by immunohistochemical staining in whole biopsy and intrafollicular areas. (M) Representative images of immunohistochemical staining patterns of BCL-rambo expression (left, original magnification ×5; right, original magnification ×20). (N) BCL-rambo expression levels identified by MS-based proteomics. (O) BCL-rambo expression levels identified by immunohistochemical staining in whole biopsy and intrafollicular areas. ▪P < .1; ∗P < .05; ∗∗P < .01; ∗∗∗P < .001. AF, area fraction.

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