Alterations of coagulation factor activity after arenavirus-induced HF. (A) Factors of the intrinsic pathway of coagulation: factors XII, XI, IX, and VIII. (B) Factors of the extrinsic and common pathway: factors II, V, VII, and X. Tests were performed using EDTA plasma for GTOV and MACV and citrate plasma for LASV Josiah and AV. The legend is as for Figure 2. The base level is calculated as the mean of all values from 3 mock-infected animals and the value at the day of challenge of 6 infected animals. Three animals of each infection status were included.