Histopathological changes associated with hemostasis defects in the organs of infected monkeys. Samples harvested during necropsy of animals infected with MACV, GTOV, LASV Josiah, LASV AV, or mock-infected were stained using hematoxylin-eosin coloration. Black squares correspond to the area imaged in the inset on the right. Left column: lungs show varying degrees of hemorrhage, alveolar edema, and interstitial infiltration. Black arrowheads indicate areas of hemorrhage and white arrowheads indicate alveolar edema. Right column: hepatic parenchyma injury includes macrovesicular steatosis, focal necrosis and peri-portal mononuclear infiltrates. Black arrowheads indicate areas of hepatocellular degeneration and necrosis; white arrowheads indicate inflammatory infiltrates. Images are representative of observations made in 3 different animals for each condition. Left column scale bar = 100 μm; right column scale bar = 50 μm.