Figure 7.
Runx1R188Q/+ predisposes to a variety of hematologic malignancies in cooperation with other somatic mutations. (A) Kaplan-Meier survival curve of WT, Runx1R188Q/+, Runx1Δ/+, and Runx1R188Q/Δ mice. (B) Histology analysis of BM and peripheral blood of Runx1R188Q/Δ mice with HM. (C) Kaplan-Meier survival curve of mice with Runx1 mutations and NrasG12D/+ allele. (D) Histology analysis of BM, and thymus of Runx1R188Q/ΔNrasG12D/+ mice with HM. (E) Kaplan-Meier survival curve of mice treated with ethyl-nitrosourea (ENU). (F) Histology analysis of BM of ENU-treated Runx1R188Q/Δ mice.

Runx1R188Q/+ predisposes to a variety of hematologic malignancies in cooperation with other somatic mutations. (A) Kaplan-Meier survival curve of WT, Runx1R188Q/+, Runx1Δ/+, and Runx1R188Q/Δ mice. (B) Histology analysis of BM and peripheral blood of Runx1R188Q/Δ mice with HM. (C) Kaplan-Meier survival curve of mice with Runx1 mutations and NrasG12D/+ allele. (D) Histology analysis of BM, and thymus of Runx1R188Q/ΔNrasG12D/+ mice with HM. (E) Kaplan-Meier survival curve of mice treated with ethyl-nitrosourea (ENU). (F) Histology analysis of BM of ENU-treated Runx1R188Q/Δ mice.

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