The presence of ≥3 (of 5) unfavorable day 7 poor prognostic indicators is strongly associated with pre-BMT mortality. (A) Kaplan-Meier pre-BMT survival estimates based on markers obtained around day 7 of therapy. The addition of imputed data for missing values are shown in supplemental Figure 7 and gave a similar result. Survival analysis using individual day 7 markers is shown in supplemental Figure 9C. (B) An illustration of the early response assessment tool for patients receiving etoposide-based therapy indicating the need for a data-based, responsive-adaptive therapeutic strategy for HLH. Improvement = (difference between baseline and day 7 values)/baseline value; ∗∗∗∗P < .0001.