Multiple laboratory parameters have maximal discriminatory power at day 7 compared with baseline or day 14 for predicting pre-BMT mortality. (A) ROC for day 7 laboratory parameters with AUC ≥ 0.7 are shown. Cutoffs are designated by the point with the highest Youden index. (B) Day 7 and day 14 markers with strong discriminatory power (AUC ≥ 0.7) are shown at baseline (day 0), day 7, and day 14. BUN is the only significant baseline marker. All significant markers and their optimized threshold at each early timepoint are listed in supplemental Table 5. Improvement = (difference between baseline and day X)/baseline value. ALC, absolute lymphocyte; LDH, lactate dehydrogenase; Sens., sensitivity; Spec., specificity.