High gene expression of both PDL1 and PDL2 correlated with poorer outcome. (A) PFS and (B) OS according to PDL1/PDL2 gene expression status (assessed by RT-MLPSeq) in the GEP set from the PMBL LYSA cohort (n = 120). Within the GEP set (n = 120), we identified a subset of 37 of 120 patients (30.8%) with high gene expression of the PDL1 and PDL2 genes (PDL1^high/PDL2^high; cutoff: median expression of each gene: PDL1 = 0.402; PDL2 = 9.147).