Decision tree for management of patients with asymptomatic aPL. Initial risk assessment is based primarily on the antibody profile, with triple-positive patients considered highest risk. Progressively less risk is depicted by less intense shading in the red box, though grading of this risk is imprecise. Patients with significant cardiovascular risk factors might also benefit from statins (blue box) and patients with rheumatologic symptoms, even without diagnostic serologies, from hydroxychloroquine. ASCVD, atherosclerotic cardiovascular disease; EULAR, European Alliance of Associations for Rheumatology; LAC, lupus anticoagulant; LDA, low dose aspirin.