Clinical case 3: thrombotic thrombocytopenic purpura (TTP). (A) Patient presented with severe and selective thrombocytopenia (blue). Platelets did not improve after intravenous immunoglobulin (IVIG) treatment for presumptive immune thrombocytopenia (ITP). Patient developed a progressive decrease in hemoglobin (orange), and markers of hemolysis consistent with a microangiopathic anemia. Platelet count normalized with plasmapheresis and steroids. INR, international normalized ratio; LDH, lactate dehydrogenase; MCV, mean corpuscular hemoglobin; WBC, white blood cells. (B) PLASMIC score was high, compatible with TTP.