Clinical implications of changing risk stratifications using IPSS-M. (A) IPSS-M risk groups and the equivalent risk group using the prior IPSS-R criteria. Dashed lines outline unchanged risk classes based on either model. Adapted from Bernard et al.²  (B) Comparison of median overall survival based on IPSS-R and IPSS-M in the indicated studies. Pie charts show groupings of patients into the different IPSS-M risk categories.