Therapeutic doses of fresh frozen plasma (FFP) on international normalized ratio (INR) and endogenous thrombin potential (ETP). (A) INR and (B) ETP measured in the presence of thrombomodulin in 19 patients with chronic liver disease and a prolonged INR before and after FFP administration, compared with controls (n = 20). Bars represent median ± interquartile ranges. *P < .05. ****P < .0001, before vs after FFP transfusion. ^##P < .01, patients vs controls. ^####P < .0001, patients vs controls. Adapted from with permission from Elsevier Inc.²⁸