Peripheral blood film from a patient with PK deficiency with an intact spleen (A) and after splenectomy (B). The red cell findings in PK deficiency with an intact spleen are mild. Nonspecific or bland red cell morphology in a patient with a congenital hemolytic anemia should raise suspicion for an enzymopathy. After splenectomy, the peripheral blood film is notable for moderate polychromasia and echinocytes.