Management options for AdvSM. HR, high risk; Plts, platelets. *If AHN is the major component contributing to patient symptoms. Reproduced with permission from Radia DH, Moonim MT. Update on diagnostic approaches and therapeutic strategies in systemic mastocytosis. Best Pract Res Clin Haematol. 2022;35(2):101380. doi:10.1016/j.beha.2022.101380.